It was aborted 20 minutes before launch at Kennedy Space Centre in Florida.
Another attempt will be made to relaunch it on Saturday 30 May.
The SpaceX launch was set to be the first manned spaceflight from U.S. soil in nearly a decade.
But bad weather was long predicted as a possible impediment to the launch.
“Unfortunately, we are not going to launch today,” SpaceX launch director Mike Taylor told NASA astronauts Bob Behnken and Doug Hurley.
The U.S. has been sending astronauts to the ISS, in collaboration with the Russians for the past 10 years.
Commenters on social media however blamed President Donald Trump for “jinxing” the launch with their unnecessary visit to the Space Center.